| Notes |
- Thymidine analogue, active against DNA viruses (herpesviruses,
poxviruses). (B553.44.w44)
- Active against HSV-1, VZV and some other herpesviruses. (J549.30.w1)
- This drug is phosphorylated intracellularly to form BVDU
5'-triphosphate.(J549.30.w1)
- Both the first and
second phosphorylation steps are catalysed by viral-encoded proteins
(HSV-1 TK, VZV TK), therefore t he drug is specific for these viruses. (J549.30.w1)
- Inhibits DNA synthesis. (B135.49.w49)
- BVDU
5'-triphosphate can act as a competitive inhibitor, with
respect to the normal substrate of dTTP, of viral DNA polymerase.
Alternatively
it acts as an alternative substrate, is incorporated into viral DNA
and causes reduced DNA integrity and functioning. (J549.30.w1)
- Inside the host cell it is phosphorylated then incorporated into DNA
during synthesis. (B553.44.w44)
- DNA containing trifluridine is thought to be more susceptible to
breakage, and if transcribed results in faulty proteins. (B553.44.w44)
- Compared with Idoxuridine, higher
activity and has a higher affinity for viral rather than mammalian
DNA. (B553.44.w44)
- Not suitable for systemic use due to toxicity. (B553.44.w44)
- Side effects include leucopaenia, hepatotoxocoity and GIT
toxicity. (B553.44.w44)
|
