Chemicals / Complex Chemical Agents/ Chemical:
Carfentanil (with special reference to Bears)

INFORMATION AVAILABLE

GENERAL CHEMICAL INFORMATION THERAPEUTIC INFORMATION [DOSE, FREQUENCY & ROUTE]

NUTRITIONAL INFORMATION

TOXICITY INFORMATION ENVIRONMENTAL INFORMATION
Information in this page has been entered to support the current volumes of Wildpro and further information will be added as new volumes are completed. This page is not intended to substitute for the manufacturer's data sheet and the information is not yet complete for all species, or for all contra-indications etc.

CAUTION: Before any pharmaceutical product is used, the manufacturer's data sheet, containing information on uses, dosage and administration, contra-indications, warnings etc., should always be consulted. It is important to remember that licensing of pharmaceutical products for use in a particular species/condition, as well as mandatory meat and milk withdrawal times for food-producing animals, varies between countries and changes with time. Withdrawal times also may vary between different pharmaceutical formulations and depending on route of administration. In Europe the prescription cascade must be followed. In the USA FARAD may be consulted regarding residues and meat and milk withdrawal times.

General Chemical Information

Summary 
Carfentanil is a highly potent, rapidly acting opiate agonist. 

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Names and Formulae
Type Opiate, a 4-amino-piperazine derivative; (B70.A1.w) a fentanyl analogue. (W652.Nov06.w1)
Alternative Names Methyl 4- (1-oxopropyl) phenylamino-1- (2 phenylethyl) -4-piperidine carboxylate-2 hydroxy-1, 2, 3-propanetricarboxylate (1:1). (W652.Nov06.w1)
Chemical Formula --
Chemical Structure --
Molecular Weight --
Related Chemicals Fentanyl. Carfentanil is about 100 times as potent as fentanyl and 10,000 times as potent as morphine. (W652.Nov06.w1)

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Physical Properties / Chemistry
Appearance

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Melting point --
Boiling point --
Density --
Water solubility --
Other solubility --
Acid/Base --

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Pharmacology & General Information
Pharmacology --
Storage / Stability --
Legal Category (In UK)
  • Carfentanil is a controlled drug in the UK. (B407.w18)

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References

Associated Techniques

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ORGANISATIONS

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ELECTRONIC LIBRARY
(Further Reading)
Click image for full contents list of ELECTRONIC LIBRARY

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Authors Debra Bourne (V.w5)
Referees Suzanne I. Boardman (V.w6)

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Therapeutic Information

Uses/Indications
Activity --
Appropriate Use Mainly used for capture of large North American hoofstock (not including equids). (W652.Nov06.w1)
Limitations
  • Effects in equids are variable. (W652.Nov06.w1)
Notes --

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Pharmacokinetics and Drug Interactions
Absorption /Bioavailability --
Distribution --
Plasma Protein binding / Storage --
Elimination Route --
Elimination half-life / Clearance Rate --
Drug Interactions --

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Administration
Formulations available Carfentanil citrate (Wildlife Pharmaceuticals). (W652.Nov06.w1)
  • Carfentanil citrate is compounded in a 10 mL vial at 3 mg/mL. (W652.Nov06.w1)
Doses / Administration Routes / Frequencies Administer by deep intramuscular injection into a large muscle mass (neck, shoulder, back or hindquarters). (W652.Nov06.w1)

In Cervidae - Deer (Family), a dose range of 0.005 - 0.020 mg/kg is safe and effective (use the lower end of the range for calm, confined animals and those in poor condition, and the top end for excited animals and those which have been pursued, or when a very quick knock-down is required. (W652.Nov06.w1)

In Bears (Ursidae - Bears (Family)):

For information on reversal see Carfentanil Anaesthesia in Bears

Monitoring parameters Monitor temperature, pulse and respiration. (W652.Nov06.w1)

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Withdrawal period / Withholding time
Notes --

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Toxic Information

Toxic effects of Pharmaceutical Products
Contraindications / Precautions
  • Never use if an adequate amount of naltrexone hydrochloride (reversal agent) is not available. (W652.Nov06.w1)
  • Do not use in individuals showing signs of severe cardiovascular or respiratory disease. (W652.Nov06.w1)
  • Avoid using during the breeding season. (W652.Nov06.w1)
  • Do not use at ambient temperatures above 100 F (38.1 C). (W652.Nov06.w1)
  • Protect the eyes during recumbency, providing shading and if possible a bland ophthalmologic ointment. (W652.Nov06.w1)
  • Ensure an appropriate head and neck position to maintain the airway and prevent aspiration of stomach contents. (W652.Nov06.w1)
Adverse Effects / Side Effects / Warnings
Operator Warnings
  • Carfentanil is highly dangerous in humans. (B407.w18)
In humans, may cause severe central nervous system depression. (W652.Nov06.w1)

"Carfentanil citrate must be treated with extreme respect and caution. Since carfentanil may be employed in locations distant from emergency medical facilities, users must ALWAYS observe the following PRECAUTIONS:

  1. User should SEEK PROFESSIONAL MEDICAL ATTENTION IMMEDIATELY if the drug is accidentally ingested or injected.
  2. At least two people in the field team should be able to RECOGNIZE SIGNS OF TOXICITY and have FIRST AID KITS containing resuscitation aids available.
  3. WORK IN PAIRS when loading syringes or darts with carfentanil. Wear rubber gloves when loading syringes to avoid accidental spills on hands.
  4. DO NOT SPRAY, squirt or spill the drug when filling syringes.
  5. WASH AT ONCE with large volumes of water if carfentanil comes in contact with skin or mucous membranes.
  6. PRACTICE GOOD CLINICAL TECHNIQUE. Do not hold used needles in mouth. Always insure that darts and syringes contain proper dose.
  7. All reasonable efforts should be made to LOCATE and RETRIEVE any loaded DARTS that missed the target animal.
  8. RESPECT all dart guns, darts and delivery syringes as though they were loaded."

(W652.Nov06.w1)

Overdose / Acute Toxicity --

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Detailed Toxicological Information
Classification --
Acute Toxicity --
Chronic Toxicity --
Reproductive effects --
Teratogenic effects --
Mutagenic effects --
Carcinogenic effects

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Organ toxicity --
Bird Toxicity --
Aquatic organism activity --
Other organism toxicity --

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Nutrient Information

Nutritional Data
Sources --
Biological Use --
Recommended Daily Allowance / Recommended level in food --
Stability in food (Storage time) --
Interactions --

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External / Environmental Information

External / Environmental Uses
Use --
Formulation --
Application method --
Application Concentration --
Persistence of Effect / Frequency of Application --

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Sources in the Environment
Natural sources --
Human-associated sources

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Effects on the Environment
Effects in the aquatic environment

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Effects on land --

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Persistence in the Environment
Breakdown in soil and groundwater

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Breakdown in water --
Breakdown in vegetation --

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