CHEMICALS SUMMARY PAGE

Cholestyramine resin

Summary Information
Classification Chemicals / Complex Chemical Agents / Type:

(This chemicals section is currently predominantly used in Wildpro to link different data types and demonstrate inter-relationships. It does not contain detailed information on the chemical itself.)

Alternative Names --
Notes Information in this page has been entered to support the current volumes of Wildpro and further information will be added as new volumes are completed. This page is not intended to substitute for the manufacturer's data sheet and the information is not yet complete for all species, or for all contra-indications etc.

CAUTION: Before any pharmaceutical product is used, the manufacturer's data sheet, containing information on uses, dosage and administration, contra-indications, warnings etc., should always be consulted. It is important to remember that licensing of pharmaceutical products for use in a particular species/condition, as well as mandatory meat and milk withdrawal times for food-producing animals, varies between countries and changes with time. Withdrawal times also may vary between different pharmaceutical formulations and depending on route of administration. In the EU, the prescription cascade must be followed (see LCofC1.2H and W564.Apr05.w1); note that specific restrictions apply for food-producing animals. In the USA, FARAD may be consulted regarding residues and meat and milk withdrawal times.

  • "Cholestyramine is a basic anion exchange resin that binds to acidic side chains such as those occurring in bile acids." The number of binding sites of cholestyramine is increased by attachment to a polystyrene matrix which is able to act as a nonspecific adsorbent. (B553.49.w49)
  • This is an ion exchange resin. It removes bile acids from the gut before reabsorption, thereby increasing the rate of cholesterol metabolism. Additionally, it binds fat-soluble and bacterial toxins including clostridial iota toxins in the gut. (B603.5.w5, B609.2.w2)
  • Cholestyramine resin binds bile acids and endotoxin within the intestinal lumen. (B553.49.w49)
  • In humans, cholestyramine resin is used in the control of syndromes involving hypercholesterolaemia, and in therapy of intractable diarrhoea. (B553.49.w49)
  • As well as bile salts, lipoprotein, cholesterol and neutral fats are bound, decreasing their absorption from the GIT. (B553.49.w49)
  • Used in the treatment of pruritis associated with increased bile acids. (B553.49.w49)
  • Undesirable side effects can include nausea, constipation, steatorrhoea and reduced absorption of fat-soluble vitamins. (B553.49.w49)
Administration
  • Give in food or water. (B553.49.w49)

Lagomorphs - Oryctolagus cuniculus domesticus - Domestic rabbit:

  • 2 g per adult rabbit, daily for two weeks. (B373.Guide.w41)
  • 0.5 g/kg orally on food every 12 hours. For the prevention/treatment of rabbits at risk of developing enterotoxaemia. (B603.5.w5)
  • 2.0 g per rabbit, with 20 mL water, given gently orally by syringe. For absorption of toxins following overgrowth of Clostridium in the gastrointestinal tract. (B546)
  • 2 g in 20 ml of water given by gavage every twenty four hours for up to eighteen to twenty one days. This dose is reportedly effective in preventing death in rabbits suffering from acute clostridial enterotoxaemia. See: Clostridial Enteritis and Enterotoxicosis in Rabbits. (B609.2.w2)
  • 500 mg/kg orally every 12 hours. (B601.15.w15)
  • 2 g in 20 mL water daily was used successfully experimentally to prevent enterotoxaemia induced by oral administration of Clindamycin. (J83.26.w1)

Great Apes

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