|
Drug
Interactions |
- May inhibit the hepatic microsomal enzyme system; metabolism of
other drugs may therefore be reduced, resulting in prolonged serum
half-life and increased serum concentrations. Additionally, hepatic
blood flow may be reduced, reducing the first-pass effect on some
drugs. (B263)
- Drugs whose metabolism may be affected by cimetidine include:
"beta-blockers (e.g., propranolol), lidocaine, calcium channel blockers (e.g., verapamil), diazepam (and other
benzodiazepines), ethanol, metronidazole, phenytoin, quinidine,
theophylline, and warfarin." (B263)
- It may be necessary to adjust dosages and/or increase
therapeutic
monitoring of the effects of affected drugs. (B263)
- May decrease renal clearance of procainamide. (B263)
- "May exacerbate leukopenias when used with other agents that can cause this
problem." (B263)
- If any antacids, metoclopramide, sucralfate, digoxin or
ketoconazole are also being used in the same individual, then avoid
giving at the same time - preferably administer at least two hours
apart. (B263)
Physical interactions
Cimetidine Injectable product is reported physically compatible
with: "acetazolamide sodium, amikacin sulfate,
atropine sulfate, carbenicillin disodium, cefoxitin sodium, chlorothiazide sodium, clindamycin
phosphate, colistimethate sodium, dexamethasone sodium phosphate, digoxin, epinephrine,
erythromycin lactobionate, furosemide, gentamicin sulfate, heparin sodium, insulin (regular),
isoproterenol HCl, lidocaine HCl, lincomycin HCl, methylprednisolone sodium
succinate, nafcillin sodium, norepinephrine bitartrate, penicillin G potassium/sodium,
phytonadione, polymyxin B sulfate, potassium chloride, protamine sulfate, quinidine
gluconate, sodium nitroprusside, tetracycline HCl, vancomycin HCl, verapamil
HCl, and vitamin B complex (w/ or w/o C)" also with commonly used
solutions for intravenous infusions (including amino acid (total
parenteral nutrition) solutions), if used within 48 hours of dilution. (B263)
Reported physically incompatible with (or conflicting data on
comptability): "amphotericin B, ampicillin sodium, cefamandole
naftate, cefazolin sodium, cephalothin sodium, and pentobarbital sodium." (B263)
Note: Physical compatibility is affected by factors such as
concentration, pH,
temperature and diluents; specialized references should be consulted
for more specific information. (B263)
|
