CHEMICALS SUMMARY PAGE

Glycopyrrolate

Summary Information
Classification Chemicals / Complex Chemical Agents / Type:

(This chemicals section is currently predominantly used in Wildpro to link different data types and demonstrate inter-relationships. It does not contain detailed information on the chemical itself.)

Alternative Names Glycopyrronium
Notes Information in this page has been entered to support the current volumes of Wildpro and further information will be added as new volumes are completed. This page is not intended to substitute for the manufacturer's data sheet and the information is not yet complete for all species, or for all contra-indications etc.

CAUTION: Before any pharmaceutical product is used, the manufacturer's data sheet, containing information on uses, dosage and administration, contra-indications, warnings etc., should always be consulted. It is important to remember that licensing of pharmaceutical products for use in a particular species/condition, as well as mandatory meat and milk withdrawal times for food-producing animals, varies between countries and changes with time. Withdrawal times also may vary between different pharmaceutical formulations and depending on route of administration. In the EU, the prescription cascade must be followed (see LCofC1.2H and W564.Apr05.w1); note that specific restrictions apply for food-producing animals. In the USA, FARAD may be consulted regarding residues and meat and milk withdrawal times.

Anticholinergic. Reverses parasympathetic effects by blocking the action of acetylcholine at muscarinic receptors at the terminal ends of the parasympathetic nervous system. Due to its quaternary structure, glycopyrrolate does not cross the blood-brain barrier, therefore does not cause any central effects. It has a longer duration of action than Atropine Sulphate. (B546)

Glycopyrrolate is a potent antisialagogue i.e. it decreases the volume of oral and bronchial secretions, therefore it has been used as an anaesthetic pre-medicant. However, it does this by decreasing the water content of those secretions, therefore the secretions become more viscous (sticky). Glycoptrrolate is also used for inhibition of vagal efferent activity and management of bradycardias due to potent opioids. It does not cause mydriasis, because it does not have central effects. (B546)

Administration

Lagomorphs - Oryctolagus cuniculus domesticus - Domestic rabbit:

  • 0.01 mg/kg intravenously or  0.1 mg/kg subcutaneously or intramuscularly as a premedicant and for organophosphate poisoning. Note: does not cross the blood-brain barrier, therefore does not cause mydriasis. (B600.4.w4)
  • 11 g/kg intravenously or intramuscularly, once. (B546)
  • 0.01 mg/kg intravenously. For prevention of bradycardia in the treatment of cardiac arrhythmia (Cardiac Arrhythmia in Rabbits). Monitor heart rate and rhythm. (B601.10.w10)
  • 0.1 mg/kg subcutaneously or intramuscularly. In the treatment of organophosphate poisoning. (B601.15.w15)

Ferrets - Mustela putorius furo - Ferret:

  • 0.01 mg/kg intramuscularly. (B602.41.w41)
  • 0.1 mg/kg intramuscularly. (B626.App.w22)
  • 0.02 mg/kg intramuscularly.(B631.22.w22)
  • 0.01 mg/kg intramuscularly or subcutaneously. (J213.3.w1)

Great Apes

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