Chemicals / Complex Chemical Agents/ Chemical:
Fipronil (with special reference to Hedgehogs and Ferrets)

INFORMATION AVAILABLE

GENERAL CHEMICAL INFORMATION THERAPEUTIC INFORMATION [DOSE, FREQUENCY & ROUTE]

NUTRITIONAL INFORMATION

TOXICITY INFORMATION ENVIRONMENTAL INFORMATION
Information in this page has been entered to support the current volumes of Wildpro and further information will be added as new volumes are completed. This page is not intended to substitute for the manufacturer's data sheet and the information is not yet complete for all species, or for all contra-indications etc.

CAUTION: Before any pharmaceutical product is used, the manufacturer's data sheet, containing information on uses, dosage and administration, contra-indications, warnings etc., should always be consulted. It is important to remember that licensing of pharmaceutical products for use in a particular species/condition, as well as mandatory meat and milk withdrawal times for food-producing animals, varies between countries and changes with time. Withdrawal times also may vary between different pharmaceutical formulations and depending on route of administration. In the EU, the prescription cascade must be followed (see LCofC1.2H and W564.Apr05.w1); note that specific restrictions apply for food-producing animals. In the USA, FARAD may be consulted regarding residues and meat and milk withdrawal times.

General Chemical Information

Summary 
Ectoparasiticide, used against fleas and ticks. (B263, B201)

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Names and Formulae
Type Phenylpyrazole antiparasitic agent. (B201.2.w2, B263)
Alternative Names "MB 46030; Regent; 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1H-pyrazole-3-carbonitrile; Pyrazole-3-carbonitrile, 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-." (W324)
Chemical Formula C12H4Cl2F6N4OS (W324)
Chemical Structure --
Molecular Weight 437.1462 (W324)
Related Chemicals --

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Physical Properties / Chemistry
Appearance

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Melting point --
Boiling point --
Density --
Water solubility --
Other solubility --
Acid/Base --

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Pharmacology & General Information
Pharmacology
  • Disrupts central nervous system activity in insects by interfering with the passage of chloride ions in GABA -regulated chloride channels. Causes rapid death of the invertebrate. (B201.2.w2, B263)
Storage / Stability
  • Commercially available solutions: store at room temperature; keep from heat and open flame (flammable). (B263)
Legal Category (In UK) --

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References

Associated Techniques

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ORGANISATIONS

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ELECTRONIC LIBRARY
(Further Reading)
Click image for full contents list of ELECTRONIC LIBRARY

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Authors Debra Bourne (V.w5)
Referees Suzanne I. Boardman (V.w6); Becki Lawson (V.w26)

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Therapeutic Information

Uses/Indications
Activity
  • Active against invertebrates including fleas and ticks. (B201.2.w2, B263)
    • Kills fleas before they can lay eggs. (B201.2.w2)
    • Provides protection against re-infestation with fleas for a variable period (e.g. five weeks to three months) depending on the product application (spray or spot-on) and the host species (cat or dog). (B201.2.w2)
    • Provides protection against ticks on dogs for up to four weeks. (B201.2.w2)
Appropriate Use
  • Cats and dogs: for treatment of fleas and ticks. (B201.2.w2, B263)
    • Spray may be used on puppies/kittens more than two days old. (B201.2.w2)
  • Other species: for treatment of fleas and ticks (not an "approved" use). (B263)
  • May assist in controlling lice, Sarcoptes mites, Cheyletiella mites and Neotrombicula mites. (B201.2.w2)
Limitations
  • Spray is not approved for use in kittens/puppies under two days old. (B201.2.w2)
  • Spot-on is not approved for use in kittens under twelve weeks old or puppies under ten weeks old. (B201.2.w2)
Notes --

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Pharmacokinetics and Drug Interactions
Absorption /Bioavailability --
Distribution
  • Following topical application, apparently spreads over the body by translocation (over whole body in about 25 hours). (B263)
  • Manufacturers information: collects in skin oils and hair follicles, then released over a long period of time. (B263)
Plasma Protein binding / Storage --
Elimination Route --
Elimination half-life / Clearance Rate --
Drug Interactions
  • No information available. (B263)

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Administration
Formulations available In UK:
Doses / Administration Routes / Frequencies

Use of Drugs (Medication):

  • Before administration of any pharmaceutical product the manufacturer's datasheet must be consulted regarding operator safety, relevant withdrawal times etc.
  • Many drugs are not registered for use in particular species and additional care should be taken in their use, with proper regard for possible toxic effects. 
  • Consideration should be given to relevant legislation regarding the use of drugs.
  • In the UK, guidelines regarding the use of drugs are set out in the Royal College of Veterinary Surgeons' Guide to Professional Conduct 2000: (See: LCofC1 - RCVS Guide to Professional Conduct 2000 - Choice of Medicinal Products).

Erinaceus europaeus - West European Hedgehog:

  • Topical. (J15.21.w1)
  • Spray sparingly. For treatment of Flea Infection and Tick Infection. Ensure the hedgehog is kept in a well-ventilated area during and after treatment. (B284.6.w6)
  • Frontline spray (Merial Animal Health). Maximum 3 ml/kg. Topical. (D107)

Ferrets - Mustela putorius furo - Ferret:

  • One pump of the spray or a third of a cat tube every 30 - 60 days. (B602.41.w41)
  • 2.5 g/L, two to three sprays per ferret. For fleas. "No toxicity seen. Easy to use with colony ferrets. (Do not use on pregnant jills)."(B626.App.w22)
  • 0.2 - 0.4 mL topically every 30 days. (B631.21.w21)
  • 0.2 - 0.4 mL topically, once monthly (tubes of 0.4 mL, 1.9% solution). (J213.3.w1)
Monitoring parameters --

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Withdrawal period / Withholding time
Notes Before the use of any pharmaceutical product in food-producing animals the label instructions for the product should be consulted regarding withdrawal requirements.

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Toxic Information

Toxic effects of Pharmaceutical Products
Contraindications / Precautions
  • May be harmful to individuals which are debilitated, aged, pregnant or nursing. (B263)
  • Contraindicated in rabbits: deaths have occurred following application of spray. (B263)
  • Avoid use in individuals which have shown sensitivity reactions to the drug or to any of the ingredients in the commercially available products. (B263)
  • Spray is contra-indicated for use on puppies or kittens less than two days old. (B201.2.w2)
  • Do not bath the animal within two days of application. (B201.2.w2)
Adverse Effects / Side Effects / Warnings
  • Temporary irritation may occur at the sprayed site. (B263)
  • Rare hypersensitivity reactions reported. (B263)
  • Cat: hypersalivation may occur if an individual licks the area to which the "spot-on" formulation has been applied. (B201.2.w2)
  • Safety of "spot-on" application has not been established for puppies under ten weeks old or kittens under 12 weeks old. (B201.2.w2)
Operator Warnings
  • Before the use of any pharmaceutical product the label instructions for the product should be consulted regarding operator safety/warnings.
  • Avoid contact. 
    • Latex gloves should be worn while the product is applied. (B263)
    • Contact with the animal treated should be avoided until the product has dried. (B201.2.w2, B263)
    • Recently-treated animals should not be allowed to sleep with humans (particularly children). (B201.2.w2)
Overdose / Acute Toxicity --

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Detailed Toxicological Information
Classification --
Acute Toxicity
  • Dogs: 
    • No adverse effects following application of five times maximum approved dose. (B263)
    • No adverse effects following ingestion of 640 mg/k fipronil. (B263)
  • Cats:
    • No adverse effects following application of five times maximum approved dose. (B263)
    • No adverse effects following ingestion of 320 mg/k fipronil. (B263)
Chronic Toxicity --
Reproductive effects --
Teratogenic effects --
Mutagenic effects --
Carcinogenic effects

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Organ toxicity --
Bird Toxicity --
Aquatic organism activity --
Other organism toxicity --

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Nutrient Information

Nutritional Data
Sources --
Biological Use --
Recommended Daily Allowance / Recommended level in food --
Stability in food (Storage time) --
Interactions --

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External / Environmental Information

External / Environmental Uses
Use --
Formulation --
Application method --
Application Concentration --
Persistence of Effect / Frequency of Application --

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Effects on the Environment
Effects in the aquatic environment

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Effects on land --

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Persistence in the Environment
Breakdown in soil and groundwater

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Breakdown in water --
Breakdown in vegetation --

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