Glossary & References / Keywords List / Definitions:

Term to be defined Definition Synonyms & Keywords
PrPSc -"The abnormal disease-causing isoform of the normal cellular protein PrPC. Conversion into this form involves a conformational change with the alpha-helical content decreasing while the beta sheet content increases. The structural change is accompanied by changes in the protein's properties, from being soluble in nondenaturing detergents to being insoluble in these and from being readily digested by proteases to being partially resistant to proteases." (J22.278.w1)

"Originally for scrapie prion protein but used for any of the disease-associated isoforms of prion protein." (J234.18.w1)

  • PrP-Sc