Glossary & References / Keywords List / Definitions:
|Term to be defined||Definition||Synonyms & Keywords|
disease-causing isoform of the normal cellular protein PrPC.
Conversion into this form involves a conformational change with the
alpha-helical content decreasing while the beta sheet content increases.
The structural change is accompanied by changes in the protein's
properties, from being soluble in nondenaturing detergents to being
insoluble in these and from being readily digested by proteases to being
partially resistant to proteases." (J22.278.w1)
"Originally for scrapie prion protein but used for any of the disease-associated isoforms of prion protein." (J234.18.w1)