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Assessment of the Organophosphates
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Hazard Assessment of the Organophosphates
Report of the
A Note to Readers:
This draft report contains the most current acute and chronic toxicological information on the organophosphates for the purpose of conducting human health risk assessments. This report represents the Office of Pesticide Programs' science on hazard identification for the organophosphates at this point in time. However, it should be recognized that we are beginning a process of public comment on the full preliminary risk assessments for each of the organophosphate pesticides. Hazard identification is the first step of the risk assessment process and is subject to change based on information we receive in response to the full preliminary risk assessments.
Also contained in this document are some preliminary suggestions on the 10X margin of safety for children. The Pesticide Programs' FQPA Safety Factor Committee is refining these safety factors for the organophosphates based on our current science policy and standard operating procedures. Therefore, we caution against any use of this portion of the document out of context. This FOIA did also request the completed review from the FQPA Safety Factor Committee, which the Agency is currently working to complete and will made available shortly.
Indeed, scientific documents of this sort always reflect only the work and analysis conducted at the time they are produced. It is common and appropriate that, as new information becomes available and/or additional analyses are performed, the conclusions may change.
The U.S. food supply is among the safest in the world. Leading health experts recommend that people eat five servings of fruits and vegetables a day, along with a variety of foods. Through implementation of the Agency's tolerance reassessment program, as mandated by Food Quality Protection Act, the food supply will become even safer.
July 22, 1998
Health Effects Division
July 7, 1998
Committee Members in Attendance
Members present were: Karl Baetcke, William Burnam, Steven Dapson (for Sue Makris), Karen Hamernik, Robert Fricke, Nancy McCarroll, Michael Metzger (Co-Chairman), Melba Morrow, John Redden, Jess Rowland (Executive Secretary) and Clark Swentzel (Chairman), HED staff (non-members) who participated in this reassessment were: Kathleen Raffaele of Toxicology Branch 2 and William Sette of Science Analysis Branch.
FQPA Safety Committee members in attendance (as observers) were Ray Kent and Brenda Tarplee (Executive Secretary)
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