DISEASE SUMMARY PAGE

Trisomy 17 in a Bonobo

Summary Information

Diseases / List of Miscellaneous / Metabolic / Multifactorial Diseases / Disease summary
Alternative Names  
Disease Agents
  • Trisomy of bonobo chromosome 17, equivalent to trisomy 18 in humans. (J389.95.w1)
Infectious Agent(s) --
Non-infectious Agent(s) --
Physical Agent(s) --
General Description
  • Absence of normal nursing behaviour and progressive weakness, in the first 24 hours after birth, despite normal maternal behaviour from the mother. (J389.95.w1)
  • Anatomical abnormalities: "abnormal and asymmetric ear pinnae, left aural canal atresia and right aural canal stenosis, diminished browridge/facial flattening with small palpebral fissues, eyelid ptosis, grade 1 systolic heart murmur, agenesis of coccygeal vertebrae, lordosis, and clenched hands without overlapping fingers." On radiography, the lumbar lordosis, coccygeal vertebral agenesis and clenched hands were confirmed, plus tubularisation of the femurs was noted. At necropsy, a ventricular septal defect was found. (J389.95.w1)
Further Information
  • In human infants with trisomy 18, heart defects are seen in 50% of individuals, and weakness, auricular malformation, short palpebral fissures and clenched hands are also present in at least 50%, while ptosis of the eyelids is found in 10-50%. In humans, increased maternal age is thought to be a factor (mean maternal age 32), but the bonobo was only 15 years old. (J389.95.w1)
Associated Techniques
Host taxa groups /species
Author Dr Debra Bourne MA VetMB PhD MRCVS (V.w5)
Referees  

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