| Summary Information |
| Diseases / List of Toxic Diseases /
Disease summary |
| Alternative Names |
- Beta-Aminoproprionitrile Toxicity
- BAPN toxicity
- Lathyrism
|
| Disease Agents |
Beta-aminoproprionitrile
(BAPN), from Lathyrus odoratus - Sweetpea seeds. |
| Infectious
Agent(s) |
|
| Non-infectious
Agent(s) |
|
| Physical
Agent(s) |
-- Indirect / Secondary |
| General Description |
- Plant poisoning causing growth retardation, skeletal deformities and
death.
- Clinical signs: Growth suppression, lameness, curled
toes, enlarged hocks (sometimes discoloured green due to haemorrhage). Perosis (Perosis) (lateral rotation of one or
both legs with slipped gastrocnemius (Achilles) tendon), sometimes haemorrhages in thigh
muscles, probably trauma-related. Rib cage deformity, with sternum twisted and deviated
inward, thoracic capacity volume reduced.
(J5.9.w1).
Recorded that eating a large number of seeds may cause temporary
paralysis (species not stated - probably human).
(B103) |
| Further Information |
- Lameness by one week at 0.1% of feed .
- Mortality is dose-dependant. Deaths within two weeks at 0.1% of feed.
Histopathology:
- Long bones - increased depth of epiphyseal cartilage, with
decreased and irregular vascularization. Cartilage projections deep into secondary
spongiosa and columns of cartilage cells disorganized. With gentian violet stain, globules
of basophilic-staining material associated with bone canaliculi.
- Thyroid - hypertrophy and hyperplasia of thyroid follicles.
- Aorta - focal areas intimal proliferation and disruption of
internal elastic membrane after six weeks on toxic diet. Rarely focal medial
hyalinization.
N.B. .Lathyrus seeds are toxic to humans.
(J5.9.w1). |
| Techniques linked to this disease |
|
 |
| Host taxa groups /species |
|
| Disease has been reported in either the wild or
in captivity in the following WATERFOWL Species: |
Pekin ducklings,
experimental (J5.9.w1). |
|
|
| Disease has been reported in free-ranging
populations of the following WATERFOWL Species: |
-- |
| -- |
